Description

tert-Butyl 4-Chloro-2-Morpholino-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in the synthesis of targeted kinase inhibitors. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of small-molecule kinase inhibitors targeting various cancer pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• API Synthesis: Serves as a core scaffold in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) with pyrrolopyrimidine backbones.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	tert-Butyl 4-Chloro-2-Morpholino-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylate
CAS No.	1227958-31-7
Molecular Formula	C15H19ClN4O3
Molecular Weight	338.79 g/mol
Synonyms	4-Chloro-2-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-2-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate; 7H-Pyrrolo[2,3-d]pyrimidine-7-carboxylic acid, 4-chloro-2-(4-morpholinyl)-, 1,1-dimethylethyl ester; 1227958-31-7; 4-Chloro-2-morpholino-7-(tert-butoxycarbonyl)-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-2-Morpholino-7H-Pyrrolo[2,3-D]Pyrimidine-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.