Description

2-(1H-Pyrazol-1-Yl)-4-(Trifluoromethyl)Pyrimidine is a high-value heterocyclic building block featuring a pyrimidine core substituted with a pyrazole ring and a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for creating novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of potential drug candidates, particularly in areas like kinase inhibitors and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold for designing and optimizing new chemical entities in drug discovery programs.
• Agrochemical Development: Serves as a precursor in the research of novel herbicides, fungicides, and insecticides.
• Kinase Inhibitor Synthesis: The structural motif is valuable for creating compounds that modulate kinase activity, a major target class in oncology.
• Material Science Research: Potential use in developing advanced organic electronic materials or ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized, non-commercial compounds for client projects.

Basic Information

Product Name	2-(1H-Pyrazol-1-Yl)-4-(Trifluoromethyl)Pyrimidine
CAS No.	1227955-10-3
Molecular Formula	C8H5F3N4
Molecular Weight	214.15 g/mol
Synonyms	4-(Trifluoromethyl)-2-(1H-pyrazol-1-yl)pyrimidine; 2-(1H-Pyrazol-1-yl)-4-(trifluoromethyl)pyrimidine; 2-(Pyrazol-1-yl)-4-trifluoromethylpyrimidine; 1-(4-Trifluoromethylpyrimidin-2-yl)-1H-pyrazole; Pyrimidine, 2-(1H-pyrazol-1-yl)-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-(1H-Pyrazol-1-Yl)-4-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support cGMP and ISO standards for pharmaceutical and fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.