Description

4-(4-Benzylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperazine and trifluoromethyl-substituted aniline structure. This compound is essential for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is a critical building block for pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those with potential neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold in the development and scale-up of new APIs.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects.
• Chemical Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and pharmacological studies.

Basic Information

Product Name	4-(4-Benzylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline
CAS No.	1227954-35-9
Molecular Formula	C18H20F3N3
Molecular Weight	335.37 g/mol
Synonyms	1-(4-Amino-3-(trifluoromethyl)phenyl)-4-benzylpiperazine; 2-(Trifluoromethyl)-4-(4-benzylpiperazin-1-yl)aniline; 4-(4-Benzyl-1-piperazinyl)-2-(trifluoromethyl)benzenamine; 4-(4-Benzylpiperazin-1-yl)-2-(trifluoromethyl)phenylamine; Benzenamine, 4-(4-benzyl-1-piperazinyl)-2-(trifluoromethyl)-; 4-(4-Benzylpiperazin-1-yl)-α,α,α-trifluoro-o-toluidine
EINECS	Contact for details

Quality Control

Our 4-(4-Benzylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the material should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.