Description

7-Boc-2-(Methylthio)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a methylthio-substituted pyrimidine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex, biologically active molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on oncology, CNS disorders, and kinase inhibitor discovery.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of novel drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry R&D: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized to create tool compounds for studying specific enzyme functions and cellular pathways.
• Custom Synthesis: Building block for contract manufacturing organizations (CMOs) producing bespoke APIs for clinical trials.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic and organosulfur chemistry.

Basic Information

Product Name	7-Boc-2-(Methylthio)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine
CAS No.	1226776-86-8
Molecular Formula	C14H21N3O2S
Molecular Weight	295.40 g/mol
Synonyms	tert-Butyl 2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-7-ylcarbamate; 7-[(tert-Butoxycarbonyl)amino]-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 2-(Methylthio)-7-Boc-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 7-Boc-2-methylmercapto-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 7-Boc-2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 1226776-86-8; 7-Boc-2-(Methylthio)-THPP
EINECS	Contact for details

Quality Control

Our 7-Boc-2-(Methylthio)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.