Description

5-Fluoro-2-(Neopentyloxy)Aniline is a specialized aniline derivative featuring a fluorine substituent and a bulky neopentyloxy group, making it a valuable building block in advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional dyes, pigments, and organic electronic materials due to its aniline core and substituent effects.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	5-Fluoro-2-(Neopentyloxy)Aniline
CAS No.	1226156-74-6
Molecular Formula	C₁₁H₁₆FNO
Molecular Weight	197.25 g/mol
Synonyms	2-Amino-4-fluoro-1-(neopentyloxy)benzene; 5-Fluoro-2-(2,2-dimethylpropoxy)aniline; 2-(Neopentyloxy)-5-fluoroaniline; 5-Fluoro-2-(2,2-dimethylpropoxy)benzenamine; Benzenamine, 5-fluoro-2-(2,2-dimethylpropoxy)-; 5-Fluoro-2-neopentyloxyaniline
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Neopentyloxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.