Description

Rac-((2R,3S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-2-Hydroxy-4-Phenylbutanoyl)-D-Leucine CAS NO 1225383-33-4 is a sophisticated, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block (Fmoc-protected intermediate) in solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical discovery, proteomics, and bioconjugation, where high-purity, structurally defined intermediates are paramount for developing novel therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical R&D: Intermediate in the research and development of novel peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Proteomics & Biochemical Research: Used to introduce specific, non-natural residues into peptide sequences to study protein structure, function, and interactions.
• Bioconjugation: Serves as a linker or modified amino acid component in the creation of peptide-drug conjugates or labeled peptides for diagnostic applications.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify new bioactive compounds.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Rac-((2R,3S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-2-Hydroxy-4-Phenylbutanoyl)-D-Leucine
CAS No.	1225383-33-4
Molecular Formula	C35H34N2O6
Molecular Weight	578.66 g/mol
Synonyms	Fmoc-D-Leu-ψ[CH(OH)CH2]Phe-OH (racemic hydroxyethylene dipeptide isostere); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucyl-ψ[CH(OH)CH2]-L-phenylalanine (racemic); Fmoc-D-Leu-ψ[CH(OH)CH2]-L-Phe-OH; (2R,3S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutanoic acid D-leucine amide; Rac-Fmoc-D-Leu-ψ[CH(OH)CH2]Phe-OH; Hydroxyethylene dipeptide isostere of Fmoc-D-Leu-L-Phe
EINECS	Contact for details

Quality Control

Our Rac-((2R,3S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-2-Hydroxy-4-Phenylbutanoyl)-D-Leucine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.