Description

4-(5-Chloro-2-((4-Fluorobenzyl)Thio)Pyrimidine-4-Carboxamido)Butanoic Acid is a high-purity, advanced pharmaceutical intermediate designed for critical synthesis pathways. This compound matters because it provides a reliable and precisely defined building block for the development of novel active pharmaceutical ingredients (APIs), ensuring batch-to-batch consistency and traceability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of targeted therapeutics, particularly in oncology and antiviral drug development.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Manufacturing: Incorporated into the production process of active pharmaceutical ingredients requiring a functionalized pyrimidine-thioether scaffold.
• Contract Research Organizations (CROs): Supplied to CROs for custom synthesis and process development services for client projects.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies.

Basic Information

Product Name	4-(5-Chloro-2-((4-Fluorobenzyl)Thio)Pyrimidine-4-Carboxamido)Butanoic Acid
CAS No.	1225162-49-1
Molecular Formula	C₁₆H₁₅ClFN₃O₃S
Molecular Weight	383.82 g/mol
Synonyms	4-[[5-Chloro-2-[(4-fluorophenyl)methylsulfanyl]pyrimidine-4-carbonyl]amino]butanoic acid; Butanoic acid, 4-[[5-chloro-2-[[(4-fluorophenyl)methyl]thio]-4-pyrimidinyl]carbonyl]amino]-; 4-(5-Chloro-2-((4-fluorobenzyl)thio)pyrimidine-4-carboxamido)butyric acid; 1225162-49-1; 4-(5-Chloro-2-((4-fluorobenzyl)sulfanyl)pyrimidine-4-carboxamido)butanoic acid
EINECS	Contact for details

Quality Control

Our 4-(5-Chloro-2-((4-Fluorobenzyl)Thio)Pyrimidine-4-Carboxamido)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.