Description

Lys(Mmt)-Pab-Oxydiacetamide-Peg8-N3 is a specialized, multifunctional chemical building block designed for advanced bioconjugation and linker applications. This compound matters for its precise integration of a cleavable PAB linker, a photo-labile Mmt protecting group, a long-chain PEG spacer, and a terminal azide group, enabling controlled drug release and targeted delivery systems. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and antibody-drug conjugate (ADC) synthesis who require high-purity, functionalized intermediates.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Construction: Serves as a key intermediate for attaching cytotoxic drugs to monoclonal antibodies via click chemistry.
• Prodrug Development: Utilized in creating enzyme-cleavable prodrugs where the PAB moiety enables specific release of active pharmaceutical ingredients.
• Bioconjugation and Labeling: The terminal azide (N3) group allows for efficient, bioorthogonal Cu-free or strain-promoted click chemistry with alkyne-modified biomolecules.
• Peptide and Protein Modification: Used to introduce PEG chains (PEGylation) to improve solubility, stability, and pharmacokinetic properties of therapeutic peptides.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a sophisticated handle or spacer in the synthesis of complex peptide constructs.
• Diagnostic Reagent Synthesis: Employed in the development of targeted imaging agents and diagnostic probes.
• Polymer and Biomaterial Science: Functions as a functional monomer or cross-linker for creating smart, responsive hydrogels and drug-eluting materials.

Basic Information

Product Name	Lys(Mmt)-Pab-Oxydiacetamide-Peg8-N3
CAS No.	1224601-12-0
Molecular Formula	C84H128N12O26
Molecular Weight	Contact for details
Synonyms	Nε-(4-Methoxytrityl)-L-lysyl-PAB-Oxydiacetamide-PEG8-azide; Lys(Mmt)-para-Aminobenzyloxycarbonyl-Oxydiacetamide-Polyethylene glycol8-N3; Mmt-Lys-PAB-Oda-PEG8-Azide; ADC Linker-Payload Intermediate CAS 1224601-12-0; 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)benzyl (S)-2-((S)-2-(2-(2-(2-(2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetamido)-3-(4-((4-methoxyphenyl)diphenylmethoxy)amino)butanamido)propanoate; Fmoc-PAB-Oda-PEG8-N3-Lys(Mmt)-OH (related protected form); Cleavable PEG Azide Linker
EINECS	Contact for details

Quality Control

Our Lys(Mmt)-Pab-Oxydiacetamide-Peg8-N3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, impurity profile, and water content are provided with every shipment. We adhere to cGMP principles for production where applicable, supporting its use in pre-clinical and research-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.