Description

4-Chloro-6-Isopropoxyquinazoline is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound matters as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors used in oncology research. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop and scale up production of novel drug candidates. Its specific halogen and alkoxy substitution pattern makes it a versatile precursor for further functionalization.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of small-molecule kinase inhibitors for cancer treatment.
• Oncology Research: Used in the discovery and optimization of compounds targeting EGFR, VEGFR, and other tyrosine kinase pathways.
• Chemical Synthesis: Serves as a versatile scaffold for nucleophilic substitution reactions at the 4-chloro position and further modifications of the quinazoline core.
• API Development: Employed in process chemistry for the scale-up and manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Utilized in academic and industrial laboratories to study enzyme inhibition mechanisms and structure-activity relationships (SAR).

Basic Information

Product Name	4-Chloro-6-Isopropoxyquinazoline
CAS No.	1223748-36-4
Molecular Formula	C11H11ClN2O
Molecular Weight	222.67 g/mol
Synonyms	6-Isopropoxy-4-chloroquinazoline; 4-Chloro-6-(1-methylethoxy)quinazoline; 4-Chloro-6-(propan-2-yloxy)quinazoline; Quinazoline, 4-chloro-6-(1-methylethoxy)-; 1223748-36-4; 4-Chloro-6-isopropoxy-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Isopropoxyquinazoline is manufactured under cGMP-like conditions to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.