Description

4-[[(2R,3R)-3-(Benzyloxy)-2-Butyl]Oxy]-2-Chloro-5-(Trifluoromethyl)Pyrimidine is a high-purity, chiral pyrimidine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block for the development of novel active ingredients. It is primarily required by R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for agrochemical and pharmaceutical applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in antiviral and anticancer therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating novel pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Research: Serves as a valuable reagent in academic and industrial research for studying nucleophilic substitution reactions and heterocyclic chemistry.
• Process Development: Employed in scaling up synthetic routes for complex molecules requiring specific stereochemistry.
• Ligand and Catalyst Preparation: Potential precursor for the synthesis of specialized ligands used in asymmetric catalysis.

Basic Information

Product Name	4-[[(2R,3R)-3-(Benzyloxy)-2-Butyl]Oxy]-2-Chloro-5-(Trifluoromethyl)Pyrimidine
CAS No.	1223498-50-7
Molecular Formula	C₁₆H₁₈ClF₃N₂O₂
Molecular Weight	362.77 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)-4-[[(2R,3R)-3-(phenylmethoxy)-2-butyl]oxy]pyrimidine; (2R,3R)-1-Benzyloxy-2-butoxy-4-chloro-5-trifluoromethylpyrimidine; 4-[(2R,3R)-3-(Benzyloxy)butan-2-yl]oxy-2-chloro-5-(trifluoromethyl)pyrimidine; 2-Chloro-4-((2R,3R)-3-(benzyloxy)butan-2-yl)oxy-5-(trifluoromethyl)pyrimidine; CAS 1223498-50-7; Chiral Pyrimidine Derivative
EINECS	Contact for details

Quality Control

Our production of 4-[[(2R,3R)-3-(Benzyloxy)-2-Butyl]Oxy]-2-Chloro-5-(Trifluoromethyl)Pyrimidine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.