Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Dab(Ac)-Oh is a specialized, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing the unnatural amino acid 2,4-diaminobutyric acid (Dab) with orthogonal side-chain protection, enabling the precise construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, antimicrobial agents, and biochemical probes where controlled Dab incorporation is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the sequential assembly of peptide chains on resin.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation: Used to introduce reactive amine handles (after deprotection) for linking peptides to other molecules, dyes, or surfaces.
• Peptidomimetic Design: Enables the study of structure-activity relationships (SAR) by incorporating the Dab residue into non-natural peptide scaffolds.
• Biochemical Research: Tool compound for studying enzyme-substrate interactions and protein engineering.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Potential use in constructing specialized linkers that connect cytotoxic drugs to antibodies.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Dab(Ac)-Oh
CAS No.	1220955-83-8
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Fmoc-Dab(Ac)-OH; Nα-Fmoc-Nγ-acetyl-L-2,4-diaminobutyric acid; Fmoc-L-Dab(Ac)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(acetylamino)butanoic acid; Nα-Fmoc-Nγ-Ac-Dab-OH; Fmoc-Dab(Ac)-OH (Side-Chain Acetyl Protected); Fmoc-2,4-diaminobutyric acid(Ac)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-(acetyl)-L-2,4-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Dab(Ac)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for fine chemicals and can provide material for pharmaceutical development supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.