Description

Fmoc-Dap(Z-2-Cl)-Oh CAS NO 1220955-73-6 is a protected amino acid derivative, specifically an Fmoc- and Z-protected derivative of 2,3-diaminopropionic acid with a 2-chloro modification. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a unique, functionalized diaminopropionic acid residue into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity, specialized amino acids for constructing complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including enzyme inhibitors and receptor ligands.
• Bioconjugation and Probe Development: The reactive amine and carboxylic acid groups, when deprotected, allow for site-specific labeling and conjugation with other molecules.
• Peptidomimetic Design: Incorporates a modified diaminopropionic acid scaffold to create peptides with enhanced stability, bioavailability, or specific biological activity.
• Chemical Biology Studies: Serves as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Material Science: Potential use in creating functionalized surfaces or peptide-based polymers.

Basic Information

Product Name	Fmoc-Dap(Z-2-Cl)-Oh
CAS No.	1220955-73-6
Molecular Formula	C₂₆H₂₃ClN₂O₆
Molecular Weight	494.92 g/mol
Synonyms	Fmoc-Dap(2-Cl-Z)-OH; N-α-Fmoc-N-β-(2-Chlorobenzyloxycarbonyl)-L-2,3-diaminopropionic acid; Fmoc-L-Dap(2-Cl-Z)-OH; (2S)-3-[[(2-Chlorophenyl)methoxy]carbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid; Fmoc-3-[(2-Chlorobenzyloxycarbonyl)amino]-L-alanine; Fmoc-Dap(Z(2-Cl))-OH; Protected 2,3-diaminopropionic acid derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Dap(Z-2-Cl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.