Description

(5-Amino-2-Fluoro-Phenyl)-Acetonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex fluorinated aromatic structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating new molecular entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides that incorporate fluorine for enhanced activity and stability.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing the (5-amino-2-fluorophenyl)acetonitrile moiety into more complex molecules via further functionalization.
• Chemical Research & Development: Essential material for medicinal chemistry programs and process chemistry optimization in both academic and industrial R&D laboratories.
• Fluorine Chemistry Studies: A valuable compound for studying structure-activity relationships (SAR) in molecules containing both amino and fluoro substituents on an aromatic ring.

Basic Information

Product Name	(5-Amino-2-Fluoro-Phenyl)-Acetonitrile Hydrochloride
CAS No.	1220039-71-3
Molecular Formula	C8H8FN2·HCl
Molecular Weight	186.62 g/mol (Free base: 150.16 g/mol)
Synonyms	2-(5-Amino-2-fluorophenyl)acetonitrile hydrochloride; (5-Amino-2-fluorobenzyl) cyanide hydrochloride; 2-Fluoro-5-aminobenzyl cyanide hydrochloride; 2-(5-Amino-2-fluorophenyl)ethanenitrile hydrochloride; 5-Amino-2-fluorobenzeneacetonitrile hydrochloride; 2-Fluoro-5-aminophenylacetonitrile HCl
EINECS	Contact for details

Quality Control

Our (5-Amino-2-Fluoro-Phenyl)-Acetonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.