Description

Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfinylbutanoate is a sophisticated, optically active Fmoc-protected amino acid derivative. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of methionine sulfoxide residues into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing therapeutic peptides, investigating oxidative post-translational modifications, or producing complex peptide libraries. The product is supplied with a guaranteed high level of purity and stereochemical integrity to ensure reliable and reproducible synthetic outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptides containing methionine sulfoxide, a crucial residue in oxidative stress studies and native chemical ligation strategies.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates, particularly those targeting diseases where methionine oxidation plays a regulatory role.
• Bioconjugation & Protein Engineering: Serves as a precursor for creating site-specifically modified peptides or proteins for diagnostic probes, targeted drug delivery systems, and biochemical tools.
• Academic & Industrial Research: Employed in studies of protein folding, stability, and function, as methionine sulfoxide can significantly alter the physicochemical properties of peptides.
• Production of Reference Standards: Utilized to synthesize high-purity peptide standards and metabolites for analytical method development, validation, and quality control in regulated environments.

Basic Information

Product Name	Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfinylbutanoate
CAS No.	1219450-94-8
Molecular Formula	C21H23NO5S
Molecular Weight	401.48 g/mol
Synonyms	Fmoc-Met(O)-OMe; Fmoc-L-Methionine S-oxide methyl ester; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine S-oxide; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(methylsulfinyl)butanoic acid methyl ester; Fmoc-L-Methionine Sulfoxide Methyl Ester; N-α-Fmoc-L-Methionine S-Oxide Methyl Ester; Fmoc-Met(O)-Me; L-Methionine S-oxide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfinylbutanoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all relevant specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use and opened only in a dry environment to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.