Description

(Lys)-Sarafotoxin C CAS NO 1219444-22-0 is a synthetic peptide analog of the potent vasoconstrictor sarafotoxin, a member of the endothelin/sarafotoxin peptide family. This compound is a critical research tool for investigating endothelin receptor (ETA and ETB) pharmacology, signal transduction pathways, and vascular biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on cardiovascular disease, pulmonary hypertension, and cancer research.

Application

• Pharmacological Research: Used as a reference standard and agonist in studies of endothelin receptor subtypes (ETA/ETB) to understand their role in vasoconstriction and cell proliferation.
• Cardiovascular Disease Models: Employed in preclinical research to induce controlled vasoconstriction in ex vivo tissue baths or in vivo animal models of hypertension and heart failure.
• Signal Transduction Studies: A key reagent for activating G-protein coupled receptor (GPCR) pathways downstream of endothelin receptors to study intracellular calcium mobilization and other second messengers.
• Assay Development & Validation: Serves as a critical control compound in high-throughput screening (HTS) campaigns and functional assays (e.g., FLIPR, cAMP) for drug discovery programs targeting the endothelin system.
• Biochemical Characterization: Used in receptor binding assays (competitive displacement studies) to determine binding affinities (Ki, IC50) of novel therapeutic candidates.
• Academic & Institutional Research: Supports fundamental research in vascular biology, smooth muscle physiology, and the pathophysiology of diseases involving endothelin dysregulation.

Basic Information

Product Name	(Lys)-Sarafotoxin C
CAS No.	1219444-22-0
Molecular Formula	C115H174N30O31S5
Molecular Weight	2549.2 g/mol (theoretical)
Synonyms	Lys-Sarafotoxin C; [Lys2]-Sarafotoxin S6c; Sarafotoxin S6c analog; Endothelin/Sarafotoxin family peptide; ETB receptor agonist; SRTX-c (Lys2); Cys-Ser-Cys-Lys-Asn-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp
EINECS	Contact for details

Quality Control

Our (Lys)-Sarafotoxin C is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical characterization, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, aqueous acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.