Description

n-Iodoacetyl-β-(2-Naphthyl)-Alanine is a specialized, non-natural amino acid derivative designed for advanced bioconjugation and peptide chemistry. This compound matters for its role as a key building block in the synthesis of peptide-based pharmaceuticals and diagnostic agents, where it introduces a reactive iodoacetyl group for selective thiol coupling. Researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors need it for developing targeted drug conjugates, antibody-drug conjugates (ADCs), and novel biochemical probes.

Application

• Peptide Synthesis: Serves as a critical intermediate for incorporating a reactive handle into custom peptide sequences.
• Antibody-Drug Conjugate (ADC) Development: Used to create linker-payload constructs that can be selectively attached to cysteine residues on antibodies.
• Bioconjugation & Protein Labeling: Enables site-specific modification of proteins, enzymes, and other biomolecules via thiol-chemistry.
• Chemical Biology Probes: A foundational component for synthesizing activity-based probes and affinity labels to study enzyme function.
• Radiopharmaceutical Precursors: Potential use in the synthesis of precursors for diagnostic imaging agents, where the iodine can be replaced with radioisotopes.
• Materials Science: Can be used to functionalize surfaces or polymers with bioactive peptides for sensor or biomaterial applications.

Basic Information

Product Name	n-Iodoacetyl-β-(2-Naphthyl)-Alanine
CAS No.	1219437-29-2
Molecular Formula	C₁₅H₁₄INO₃
Molecular Weight	383.18 g/mol
Synonyms	N-[(Iodoacetyl)-β-(2-naphthyl)]alanine; Iodoacetamide-β-(2-naphthyl)-Alanine; N-Iodoacetyl-3-(2-naphthyl)-L-alanine; β-(2-Naphthyl)-N-iodoacetylalanine; 2-[(Iodoacetyl)amino]-3-(naphthalen-2-yl)propanoic acid; N-Iodoacetyl-β-(2-naphthyl)alanine; IAAA(2-Nal); (S)-2-(2-Iodoacetamido)-3-(naphthalen-2-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Iodoacetyl-β-(2-Naphthyl)-Alanine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates or advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.