Description

Fmoc-S-(2-(4-Pyridyl)Ethyl)-Dl-Penicillamine CAS NO 1219404-63-3 is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and chemical biology research. This compound is engineered to introduce a unique, protected thiol group and a pyridyl moiety into peptide chains, enabling precise structural modifications and the study of protein-protein interactions. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and the creation of novel therapeutic peptides and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of a modified penicillamine residue into peptide sequences.
• Bioconjugation and Linker Chemistry: The S-protected thiol group, after deprotection, serves as a reactive handle for site-specific conjugation with maleimides, halogens, or other electrophiles to attach drugs, labels, or polymers.
• Chemical Biology Research: Used to synthesize peptide-based inhibitors, probes, or model substrates to study enzyme mechanisms, receptor binding, and signal transduction pathways.
• Development of Constrained Peptides: The penicillamine structure can be utilized to induce conformational constraints or disulfide bond mimetics in peptide scaffolds to enhance stability and biological activity.
• Material Science and Surface Functionalization: The reactive thiol and aromatic pyridyl group enable the peptide-based modification of surfaces, nanoparticles, or polymers for biosensing and diagnostic applications.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and development stages of novel peptide therapeutics targeting various diseases.

Basic Information

Product Name	Fmoc-S-(2-(4-Pyridyl)Ethyl)-Dl-Penicillamine
CAS No.	1219404-63-3
Molecular Formula	C28H30N2O4S
Molecular Weight	490.62 g/mol
Synonyms	Fmoc-DL-Pen(Spy) OH; Fmoc-S-Pyridylethyl-DL-penicillamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[2-(4-pyridinyl)ethyl]-DL-penicillamine; Fmoc-DL-3,3-Dimethyl-S-(2-pyridin-4-ylethyl)cysteine; Fmoc-Pen(Spy)-OH; (R,S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethyl-4-((2-(pyridin-4-yl)ethyl)thio)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-S-(2-(4-Pyridyl)Ethyl)-Dl-Penicillamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.