Description

2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4,4,4-Trifluoro-3-Methyl-Butyric Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling the precise and efficient synthesis of complex peptides and peptidomimetics, particularly those requiring the incorporation of trifluoromethyl groups to modulate biological activity and stability. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-amino acid for the automated synthesis of therapeutic peptides containing non-natural, fluorinated side chains.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the research and development of novel drug candidates, especially protease inhibitors and GPCR-targeted therapies.
• Peptidomimetic Design: Used to introduce the sterically and electronically unique 4,4,4-trifluoro-3-methyl-butyryl moiety, enhancing metabolic stability and binding affinity in drug-like molecules.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of proteins and antibodies for diagnostic assays and targeted drug delivery systems.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and enzyme mechanisms by incorporating fluorinated analogs.
• Material Science: Potential use in the synthesis of specialized fluorinated polymers and coatings with unique surface properties.

Basic Information

Item	Details
Product Name	2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4,4,4-Trifluoro-3-Methyl-Butyric Acid
CAS No.	1219402-20-6
Molecular Formula	C20H18F3NO4
Molecular Weight	393.36 g/mol
Synonyms	Fmoc-4,4,4-trifluoro-3-methyl-DL-norvaline; Fmoc-TfmMeNva-OH; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4,4,4-trifluoro-3-methylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4,4-trifluoro-3-methyl-DL-norvaline; 4,4,4-Trifluoro-3-methyl-DL-norvaline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-3-methyl-4,4,4-trifluoronorvaline; N-Fmoc-4,4,4-trifluoro-3-methylnorvaline
EINECS	Contact for details

Quality Control

Every batch of our 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4,4,4-Trifluoro-3-Methyl-Butyric Acid is manufactured under strict quality management systems. We guarantee high purity suitable for sensitive applications like pharmaceutical research and peptide synthesis. Our comprehensive analytical suite, including HPLC, NMR, and MS, ensures identity, potency, and impurity profiles meet rigorous standards. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.