Description

Fmoc-Dl-(2-Thiazoyl)Glycine CAS NO 1219381-54-0 is a specialized, non-natural amino acid derivative featuring a thiazole side chain protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of heterocyclic motifs into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides containing the unique (2-thiazoyl)glycine residue.
• Medicinal Chemistry & Drug Discovery: Used to introduce thiazole heterocycles into peptide backbones, which can enhance binding affinity, metabolic stability, and biological activity in drug candidate molecules.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide conjugates for use in imaging, diagnostic assays, and targeted delivery systems.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms by incorporating a structurally distinct, non-canonical amino acid into synthetic peptides.
• Material Science: Potential use in the synthesis of peptidomimetic polymers or smart biomaterials with specific electronic or structural properties derived from the thiazole ring.

Basic Information

Product Name	Fmoc-Dl-(2-Thiazoyl)Glycine
CAS No.	1219381-54-0
Molecular Formula	C₂₁H₁₈N₂O₄S
Molecular Weight	394.44 g/mol
Synonyms	Fmoc-(2-thiazolyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1,3-thiazol-2-yl)-DL-alanine; Fmoc-DL-2-Thiazolylglycine; N-Fmoc-3-(2-thiazolyl)-DL-alanine; Fmoc-Thz-OH; Fmoc-2-thiazolylglycine; (RS)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(1,3-thiazol-2-yl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Dl-(2-Thiazoyl)Glycine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of peptide synthesis. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.