Description

Fmoc-Dl-Selenomethionine CAS NO 1219375-33-3 is a protected amino acid derivative where the selenomethionine side chain is shielded by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of the essential trace element selenium into synthetic peptides and proteins. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of selenopeptides for biochemical research, drug discovery, and the study of selenium's role in antioxidant enzymes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, sequential assembly of peptides containing selenomethionine residues.
• Selenoprotein Research: Used to synthesize model peptides and proteins for studying the structure, function, and catalytic mechanisms of selenoenzymes like glutathione peroxidase.
• Pharmaceutical Development: Serves as a precursor in creating therapeutic peptides and biologics where selenium incorporation is desired for stability or activity.
• Isotope Labeling Studies: A foundation for producing selenium-77 or other isotope-labeled analogues for Nuclear Magnetic Resonance (NMR) spectroscopy and metabolic tracing.
• Bioconjugation & Probe Development: The Fmoc-protected amine allows for selective deprotection and further functionalization to create labeled probes for imaging or diagnostic applications.
• Material Science: Potential use in creating bio-inspired materials and surfaces that incorporate selenium's unique chemical properties.

Basic Information

Item	Detail
Product Name	Fmoc-Dl-Selenomethionine
CAS No.	1219375-33-3
Molecular Formula	C₂₁H₂₃NO₄Se
Molecular Weight	424.37 g/mol
Synonyms	Fmoc-DL-Selenomethionine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-selenomethionine; N-Fmoc-DL-selenomethionine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylselanyl)butanoic acid; DL-Selenomethionine, N-Fmoc-; Fmoc-Selenomethionine (DL); Fmoc-DL-SeMet; N-α-Fmoc-DL-selenomethionine
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Selenomethionine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the DL-mixture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details
Solubility	Soluble in DMF, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.