Description

Rac Fmoc-Trifluoromethylalanine CAS NO 1219349-78-6 is a non-natural, fluorinated amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for introducing the metabolically stable and lipophilic trifluoromethyl group into peptide backbones, significantly altering their biological activity and physicochemical properties. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the incorporation of a trifluoromethylalanine residue into custom peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide mimetics and analogs to study structure-activity relationships (SAR), enhance metabolic stability, and improve membrane permeability.
• Bioconjugation & Probe Development: Serves as a versatile intermediate for creating fluorinated tags, imaging agents, and affinity probes due to the distinct properties of the CF3 group.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and protein-protein interactions by acting as a non-hydrolyzable or reporter amino acid substitute.
• Pharmaceutical Intermediate: A high-value building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs) with tailored properties.

Basic Information

Product Name	Rac Fmoc-Trifluoromethylalanine
CAS No.	1219349-78-6
Molecular Formula	C20H18F3NO4
Molecular Weight	393.36 g/mol
Synonyms	Fmoc-3-(trifluoromethyl)-DL-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-DL-alanine; DL-Fmoc-trifluoromethylalanine; (Rac)-Fmoc-CF3-Ala-OH; Fmoc-(±)-3-(trifluoromethyl)alanine; N-Fmoc-α-amino-β,β,β-trifluoroalanine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3,3-trifluoropropanoic acid
EINECS	Contact for details

Quality Control

Our Rac Fmoc-Trifluoromethylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Raccemic mixture
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.