Description

Fmoc-5-Benzyloxy-Dl-Tryptophan is a protected derivative of the amino acid tryptophan, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring the precise incorporation of a modified tryptophan residue into peptide chains, particularly for pharmaceutical and biochemical research applications. Its primary value lies in the dual protection offered by the Fmoc (9-fluorenylmethoxycarbonyl) group on the amine and the benzyloxy group on the indole side chain, which prevents unwanted side reactions during synthesis. This makes it an essential building block for medicinal chemists, peptide synthesis specialists, and R&D laboratories developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation and Probe Development: The modified tryptophan side chain can serve as a handle for further chemical modification or labeling in bioconjugate chemistry.
• Combinatorial Chemistry Libraries: A valuable component for creating diverse libraries of peptide compounds for high-throughput screening.
• Academic & Institutional Research: Fundamental research in biochemistry, structural biology, and chemical biology involving peptide structure-activity relationships.
• Production of Custom Peptides: Used by CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific peptide manufacturing.

Basic Information

Product Name	Fmoc-5-Benzyloxy-Dl-Tryptophan
CAS No.	1219348-47-6
Molecular Formula	C34H30N2O5
Molecular Weight	546.61 g/mol
Synonyms	Fmoc-5-Bzl-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-(phenylmethoxy)-DL-tryptophan; 5-Benzyloxy-DL-tryptophan, N-Fmoc derivative; Fmoc-Trp(5-Bzl)-OH; Nα-Fmoc-5-O-benzyl-DL-tryptophan; Fmoc-5-O-Benzyl-DL-tryptophan; DL-5-Benzyloxy-N-Fmoc-tryptophan; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-(benzyloxy)-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Benzyloxy-Dl-Tryptophan is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key specifications such as assay, chiral purity, and related substance profiles. Our quality system is designed to support research and development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.