Description

Dl-2,4-Diaminobutyric-3,3,4,4-D4 Acid Dihydrochloride is a deuterium-labeled derivative of 2,4-diaminobutyric acid, a non-proteinogenic amino acid. This stable isotope-labeled compound is essential for advanced analytical research, providing critical internal standards for mass spectrometry to ensure precise quantification and method validation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for drug metabolism and pharmacokinetic (DMPK) studies, proteomics, and biomarker discovery.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous or exogenous compounds.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying drug metabolites in biological matrices to study absorption, distribution, metabolism, and excretion (ADME).
• Proteomics and Metabolomics Research: Enables precise relative and absolute quantification of peptides, amino acids, and related metabolites in complex biological samples.
• Biochemical Pathway Tracing: Acts as a stable isotope tracer to investigate metabolic fluxes and pathways involving polyamine biosynthesis and related processes.
• Pharmaceutical Reference Standard: Provides a certified reference material for quality control and regulatory compliance in drug development and manufacturing.
• Nutritional and Biomedical Research: Supports studies on amino acid transport, neurological function, and related disorders.

Basic Information

Product Name	Dl-2,4-Diaminobutyric-3,3,4,4-D4 Acid Dihydrochloride
CAS No.	1219346-22-1
Molecular Formula	C4H5D4Cl2N2O2
Molecular Weight	200.08 g/mol (for deuterated form)
Synonyms	2,4-Diaminobutyric-3,3,4,4-d4 Acid Dihydrochloride; DL-2,4-Diamino[3,3,4,4-2H4]butyric Acid Dihydrochloride; (RS)-2,4-Diaminobutanoic-3,3,4,4-d4 Acid Dihydrochloride; 2,4-DAB-3,3,4,4-d4 Dihydrochloride; D4-2,4-Diaminobutyric Acid Dihydrochloride; Deuterated D,L-α,γ-Diaminobutyric Acid Dihydrochloride; (±)-2,4-Diamino[3,3,4,4-2H4]butyric Acid Dihydrochloride
EINECS	Contact for details

Quality Control

Our Dl-2,4-Diaminobutyric-3,3,4,4-D4 Acid Dihydrochloride is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to ISO 9001 quality management principles, and our processes are designed to meet the stringent requirements of research and pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.