Description

Fmoc-4-Methyl-Dl-Tryptophan CAS NO 1219279-39-6 is a protected amino acid derivative, a crucial building block in the synthesis of complex peptides and peptidomimetics. Its value lies in the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is selectively removable under mild basic conditions, enabling efficient solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and the production of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of custom peptides using Fmoc chemistry protocols.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of peptide-based drug candidates, particularly those targeting neurological and oncological pathways.
• Bioconjugation and Probe Development: Serves as a modified tryptophan analog for introducing specific functionalities or labels into peptides for diagnostic or imaging purposes.
• Academic and Industrial R&D: A fundamental reagent in laboratories focused on organic synthesis, medicinal chemistry, and protein engineering.
• Production of Non-Natural Peptides: Enables the incorporation of a methylated tryptophan side chain, altering peptide stability, receptor binding, and biological activity.

Basic Information

Product Name	Fmoc-4-Methyl-Dl-Tryptophan
CAS No.	1219279-39-6
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-4-Me-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-DL-tryptophan; 4-Methyl-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-4-methyltryptophan; N-Fmoc-4-methyl-DL-tryptophan; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methyl-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-4-Methyl-Dl-Tryptophan is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.