Description

Di-Fmoc-α-Methyl-Dl-Ornithine is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is engineered to provide superior control over stereochemistry and side-chain reactivity during solid-phase and solution-phase peptide assembly. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Peptide Drug Discovery: A key intermediate in the synthesis of complex peptides with modified ornithine residues for enhanced stability and bioactivity.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid monomer to incorporate α-methyl-ornithine into peptide chains, preventing racemization.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for targeted delivery and imaging.
• Enzyme Inhibitor Research: Employed in the development of substrate analogs and inhibitors for enzymes like ornithine decarboxylase.
• Chemical Biology Studies: Facilitates the study of protein-protein interactions and cellular processes using synthetic peptides with non-natural amino acids.
• GMP Manufacturing: Supports the production of Active Pharmaceutical Ingredients (APIs) for clinical and commercial peptide therapeutics under controlled conditions.

Basic Information

Product Name	Di-Fmoc-α-Methyl-Dl-Ornithine
CAS No.	1219207-80-3
Molecular Formula	C31H32N2O6
Molecular Weight	528.60 g/mol
Synonyms	Nα,Nω-Bis(9H-fluoren-9-ylmethoxycarbonyl)-α-methyl-DL-ornithine; DL-2-Amino-2-methyl-5-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; α-Methyl-DL-ornithine, N,N-bis-Fmoc-; Bis-Fmoc-α-methyl-DL-ornithine; Fmoc-α-Me-DL-Orn(Fmoc)-OH; Nα-Fmoc-Nω-Fmoc-α-methyl-DL-ornithine
EINECS	Contact for details

Quality Control

Our Di-Fmoc-α-Methyl-Dl-Ornithine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and GMP applications. Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	DL-mixture (1:1 ratio)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.