Description

2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Propanoic Acid is a sophisticated, high-purity amino acid derivative designed for advanced research and development. This compound is a critical Fmoc-protected tryptophan analog, where the indole moiety is replaced by a 7-azaindole (1H-pyrrolo[2,3-b]pyridine) group, offering unique electronic and steric properties. It is primarily required by pharmaceutical researchers and peptide chemists for the synthesis of novel peptide-based therapeutics and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the automated synthesis of peptides containing non-natural amino acids.
• Medicinal Chemistry & Drug Discovery: Incorporation into peptide libraries and lead compounds to modulate bioactivity, stability, and receptor binding affinity.
• Chemical Biology Research: Synthesis of labeled peptides and proteins for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Development of Peptidomimetics: Used to create analogs that mimic natural peptides with improved pharmacological properties.
• Bioconjugation: Potential use in the site-specific modification of biomolecules due to its reactive carboxylic acid group.
• Academic & Institutional Research: A key reagent for universities and R&D institutes exploring novel peptide structures and functions.

Basic Information

Item	Details
Product Name	2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Propanoic Acid
CAS No.	1219143-85-7
Molecular Formula	C25H21N3O4
Molecular Weight	427.46 g/mol
Synonyms	Fmoc-7-azaTrp-OH; Fmoc-β-(7-azaindol-3-yl)-L-alanine; Fmoc-L-7-azatryptophan; N-α-Fmoc-1H-pyrrolo[2,3-b]pyridin-3-yl-L-alanine; 2-({[(9H-Fluoren-9-ylmethoxy)carbonyl]amino})-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid; Fmoc-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanine; Fmoc-AzaTrp-OH; N-Fmoc-β-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our production of this advanced amino acid derivative adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral integrity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.