Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(2-Methyl-1-Piperazinyl)-4-Oxo-, Hydrobromide is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its value lies in its role as a key synthetic building block for advanced fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis and scale-up of next-generation antibacterial therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the multi-step synthesis of novel fluoroquinolone antibiotic APIs.
• Antibacterial Drug Development: Serves as a core scaffold for research into new antibacterial agents targeting resistant bacterial strains.
• Active Pharmaceutical Ingredient (API): Used directly as the active moiety in formulated antibiotic products following appropriate processing and purification.
• Process Chemistry & Scale-Up: Employed in process optimization, route scouting, and kilogram-to-ton scale manufacturing campaigns.
• Reference Standard: Utilized as a high-purity analytical standard for quality control (QC) and method validation in pharmaceutical analysis.
• Biochemical Research: Applied in microbiological and pharmacological studies to investigate structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(2-Methyl-1-Piperazinyl)-4-Oxo-, Hydrobromide
CAS No.	1219097-43-4
Molecular Formula	C19H23FN4O4 • HBr
Molecular Weight	487.33 g/mol (free base: 390.41 g/mol)
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrobromide; 7-(2-Methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrobromide; Garenoxacin Intermediate Hydrobromide; BMS-284756 Related Compound Hydrobromide Salt; T-3811 Hydrobromide; Des-F(6)-Quinolone Hydrobromide Derivative; Fluoroquinolone Antibiotic Intermediate HBr Salt
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting full compliance are available upon request, supporting regulatory filings and GMP-grade supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.