Description

(1S)-1-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Ethylamine is a high-purity chiral amine building block of significant importance in modern pharmaceutical and agrochemical research. Its core value lies in its unique molecular architecture, featuring a trifluoromethyl group and a fluorine atom on the phenyl ring, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for medicinal chemists and process development scientists engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry & Scale-up: Critical for optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	(1S)-1-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	1219093-11-4
Molecular Formula	C9H9F4N
Molecular Weight	207.17 g/mol
Synonyms	(S)-1-(2-Fluoro-4-(trifluoromethyl)phenyl)ethan-1-amine; (S)-1-[2-Fluoro-4-(trifluoromethyl)phenyl]ethylamine; (1S)-1-[2-Fluoro-4-(trifluoromethyl)phenyl]ethanamine; (S)-α-Methyl-2-fluoro-4-(trifluoromethyl)benzylamine; (S)-1-(2-Fluoro-4-trifluoromethylphenyl)ethylamine; (S)-2-Fluoro-α-methyl-4-(trifluoromethyl)benzenemethanamine; (S)-F-TFMPEA
EINECS	Contact for details

Quality Control

Our (1S)-1-[2-Fluoro-4-(trifluoromethyl)Phenyl]Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.