Description

n-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is a high-value, organoboron-protected pyrimidine derivative, serving as a critical advanced pharmaceutical intermediate (API) and Suzuki-Miyaura cross-coupling reagent. Its primary value lies in enabling efficient carbon-carbon bond formation, which is fundamental for constructing complex molecular architectures in drug discovery and material science. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for synthesizing novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic ester coupling partner for introducing the substituted pyrimidine moiety into complex molecules.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Used in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Serves as a tagged molecular probe for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific functionalized heterocycles.

Basic Information

Product Name	n-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	1218791-48-0
Molecular Formula	C14H24BN3O2
Molecular Weight	277.18 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butylpyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butylpyrimidin-2-amine; 2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butyl-; N-Butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butylpyrimidin-2-amine; CAS 1218791-48-0; BRN 19129348
EINECS	Contact for details

Quality Control

Our n-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.