Description

Fmoc-L-Selenomethionine CAS NO 1217852-49-7 is a protected, non-natural amino acid derivative where the selenol group of selenomethionine is safeguarded by the fluorenylmethyloxycarbonyl (Fmoc) group. This compound is critically important for the solid-phase peptide synthesis (SPPS) of peptides containing selenomethionine, a key amino acid for producing selenoproteins and for phasing in X-ray crystallography studies. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic research focused on selenium biochemistry, peptide therapeutics, and structural biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid for the automated synthesis of peptides containing selenomethionine residues.
• Selenoprotein Research: Key reagent for the production of selenomethionine-labeled proteins for functional and structural studies.
• X-ray Crystallography: Used in the production of selenomethionine-substituted proteins for Single-wavelength Anomalous Dispersion (SAD) or Multi-wavelength Anomalous Dispersion (MAD) phasing.
• Peptide Therapeutic Development: Incorporation into novel peptide drug candidates to study the effects of selenium substitution on activity, stability, and metabolism.
• Bioconjugation & Chemical Biology: Serves as a handle for site-specific modifications due to the unique reactivity of the selenium atom.
• Antioxidant Peptide Studies: Synthesis of model peptides to investigate the enhanced antioxidant properties imparted by selenomethionine.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for peptide and amino acid analysis.

Basic Information

Product Name	Fmoc-L-Selenomethionine
CAS No.	1217852-49-7
Molecular Formula	C₂₁H₂₃NO₄Se
Molecular Weight	424.37 g/mol
Synonyms	Fmoc-Selenomethionine; Fmoc-L-Selenomethionine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-selenomethionine; N-Fmoc-L-selenomethionine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-methylselanylbutanoic acid; Fmoc-SelMet-OH; Fmoc-SeMet; Fmoc-L-SeMet
EINECS	Contact for details

Quality Control

Our Fmoc-L-Selenomethionine is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the high standards required for peptide synthesis and research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Selenium Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.