Description

Fmoc-n-Me-His(Trt)-Oh is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide structure and function, particularly in the development of novel therapeutic agents. It is an essential building block for pharmaceutical R&D, enabling the incorporation of modified histidine residues into complex peptide sequences.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the sequential assembly of peptides on resin.
• Peptide Drug Discovery: Used to synthesize peptide libraries for screening against biological targets, especially where histidine modification is required.
• Structure-Activity Relationship (SAR) Studies: Facilitates the exploration of how methylated histidine analogs affect peptide bioactivity and stability.
• Synthesis of Bioconjugates: Serves as a precursor for creating peptide-based conjugates for drug delivery or diagnostic applications.
• Research into Enzyme Mimics & Catalysts: Used to construct peptides that mimic the metal-binding sites of natural enzymes, like those containing histidine.
• Production of Custom Peptides: Essential for CROs and CDMOs manufacturing bespoke peptides for client research and preclinical development.

Basic Information

Product Name	Fmoc-n-Me-His(Trt)-Oh
CAS No.	1217840-61-3
Molecular Formula	C41H37N3O4
Molecular Weight	635.75 g/mol
Synonyms	Fmoc-N-Methyl-His(Trt)-OH; N-α-Fmoc-N-τ-trityl-N'-methyl-L-histidine; Fmoc-N-Me-His(Trt)-OH; Fmoc-N-methylhistidine(Trt)-OH; 9-Fluorenylmethyloxycarbonyl-N-methyl-N'-trityl-histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-N'-(triphenylmethyl)-L-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-His(Trt)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals used in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.