Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-(2-Methoxy-Phenyl)Propionic Acid is a sophisticated, optically pure amino acid derivative protected with the Fmoc group, serving as a critical chiral building block in advanced organic synthesis. Its value lies in enabling the precise construction of complex peptide and peptidomimetic structures with defined stereochemistry, which is essential for developing bioactive molecules. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on producing novel therapeutics, including protease inhibitors and other targeted drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of custom peptides.
• Pharmaceutical Intermediate: For the research and development of chiral drug candidates, particularly protease inhibitors and enzyme-targeted therapies.
• Peptidomimetic Design: Used to create non-peptide compounds that mimic the structure and function of natural peptides for enhanced metabolic stability.
• Chemical Biology Probes: Incorporation into molecular probes to study enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Employed as a chiral synthon or auxiliary in the stereoselective synthesis of complex organic molecules.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic methodologies and bioactive compound libraries.

Basic Information

Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-(2-Methoxy-Phenyl)Propionic Acid
CAS No.	1217836-38-8
Molecular Formula	C25H23NO6
Molecular Weight	433.45 g/mol
Synonyms	Fmoc-(2R,3R)-3-Amino-2-hydroxy-3-(2-methoxyphenyl)propionic acid; (2R,3R)-2-Hydroxy-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-(2-methoxyphenyl)propanoic acid; Fmoc-AHPMA-OH; Fmoc-3-Amino-2-hydroxy-3-(2-methoxyphenyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-hydroxy-3-(2-methoxyphenyl)propanoic acid; (2R,3R)-Fmoc-AHPMA; (2R,3R)-3-[(Fmoc)amino]-2-hydroxy-3-(2-methoxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our production of this chiral building block adheres to strict quality protocols to ensure batch-to-batch consistency and high optical purity, critical for sensitive pharmaceutical applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral purity (>99% ee), and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.