Description

Fmoc-α-Methyl-L-Asp CAS NO 1217830-18-6 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique α-methyl aspartic acid moiety into peptide chains, a modification known to enhance metabolic stability and alter biological activity profiles. It is an essential building block for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated synthesis of complex peptides containing non-proteinogenic amino acids.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with improved pharmacokinetic properties, such as increased resistance to enzymatic degradation.
• Chemical Biology Research: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the research and development stages of new peptide-based therapeutics.
• Libraries for Screening: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	Fmoc-α-Methyl-L-Asp
CAS No.	1217830-18-6
Molecular Formula	C₂₁H₂₁NO₆
Molecular Weight	383.40 g/mol
Synonyms	Fmoc-α-Me-L-Asp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-L-aspartic acid; Fmoc-Asp(OMe)-OH (common misnomer for methyl ester, clarify); Fmoc-L-α-methylaspartic acid; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methylbutanedioic acid; Fmoc-α-methylaspartate; Protected α-methyl aspartic acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-α-Methyl-L-Asp is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.