Description

(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-Amino)-3-(4-Acetamidophenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is essential for solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins with precise stereochemistry. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical R&D: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporates the unique 4-acetamidophenyl side chain to introduce specific pharmacophores and modulate peptide properties like bioavailability and receptor binding.
• Bioconjugation & Probe Synthesis: Acts as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Supports fundamental studies in biochemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-Amino)-3-(4-Acetamidophenyl)Propanoic Acid
CAS No.	1217801-44-9
Molecular Formula	C26H24N2O5
Molecular Weight	444.48 g/mol
Synonyms	Fmoc-4-Acetamido-L-phenylalanine; Fmoc-Phe(4-Ac)-OH; Fmoc-4-Acetamidophenylalanine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-acetamidophenyl)propanoic acid; Fmoc-L-Phe(4-NHAc)-OH; N-α-Fmoc-4-acetamido-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-acetamido-L-phenylalanine
EINECS	Contact for details

Quality Control

Our (R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-Amino)-3-(4-Acetamidophenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.