Description

(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid is a high-purity, non-natural amino acid derivative featuring a thiophene side chain and an Fmoc-protected α-amino group. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides and peptidomimetics, enabling the introduction of unique structural and electronic properties. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs engaged in the development of novel therapeutic peptides, protein engineering, and chemical biology research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a direct precursor for automated peptide synthesizers, allowing for the controlled incorporation of a thiophene-containing residue into peptide chains.
• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel peptide-based drugs, including enzyme inhibitors, receptor agonists/antagonists, and diagnostic agents.
• Peptidomimetic Design: Used to create peptide analogs where the thiophene moiety mimics natural aromatic amino acids or introduces enhanced metabolic stability, lipophilicity, or specific binding interactions.
• Chemical Biology & Proteomics: Employed in the synthesis of labeled peptides, activity-based probes, and substrate analogs for studying enzyme mechanisms and protein-protein interactions.
• Material Science & Specialty Polymers: Potential use as a monomer for constructing functionalized polymers and biomaterials with specific electronic or surface properties derived from the thiophene group.

Basic Information

Product Name	(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid
CAS No.	1217774-71-4
Molecular Formula	C21H17NO4S
Molecular Weight	379.43 g/mol
Synonyms	Fmoc-3-Thienylglycine; Fmoc-Thg-OH; Fmoc-β-(3-Thienyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-thienylglycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-3-yl)acetic acid; Fmoc-L-3-thienylglycine; Nα-Fmoc-3-thienylglycine; N-Fmoc-3-thienyl-L-glycine
EINECS	Contact for details

Quality Control

Our (S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports critical applications in pharmaceutical development and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.