Description

Fmoc-D-Phe(2-Oh)-Oh is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for researchers and manufacturers developing complex peptides and peptidomimetics with enhanced stability and specific biological activity. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers focused on creating novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the controlled, sequential assembly of custom peptide chains.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation: The carboxylic acid and hydroxyl groups provide handles for linking peptides to other molecules, such as polymers, dyes, or solid supports, for creating conjugates.
• Structure-Activity Relationship (SAR) Studies: Incorporation of this modified D-phenylalanine helps researchers investigate the impact of stereochemistry and side-chain hydroxylation on peptide bioactivity and stability.
• Production of Specialty Peptides: Enables the manufacture of peptides with specific modifications for applications in biocatalysis, material science, and as research-grade biochemicals.

Basic Information

Product Name	Fmoc-D-Phe(2-Oh)-Oh
CAS No.	1217754-89-6
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-D-2-Hydroxyphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-hydroxyphenyl)-D-alanine; Fmoc-D-2-OH-Phe-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-hydroxyphenyl)propanoic acid; N-Fmoc-D-2-hydroxyphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Phe(2-Oh)-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing specific results for purity, chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.