Description

2-[(3R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Piperidin-3-Yl]Acetic Acid is a high-purity, chiral building block of significant importance in advanced organic synthesis. This compound is specifically engineered for the construction of complex molecular architectures, offering precise stereochemical control. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of peptide-based therapeutics and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative for introducing the (R)-3-piperidinylacetic acid moiety.
• Fmoc-Chemistry Reagent: Serves as an Fmoc-protected building block, enabling sequential coupling in automated peptide synthesizers.
• Chemical Biology Research: Employed in the synthesis of molecular probes, enzyme substrates, and inhibitors for studying biological pathways.
• API Development: Integral to the scalable synthesis of complex, stereochemically defined active pharmaceutical ingredients.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	2-[(3R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Piperidin-3-Yl]Acetic Acid
CAS No.	1217739-96-2
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	(R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)piperidin-3-yl)acetic acid; Fmoc-3-(R)-piperidinylacetic acid; 1-Fmoc-3-(R)-piperidineacetic acid; (R)-1-Fmoc-piperidine-3-acetic acid; (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperidine-3-acetic acid; (R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidineacetic acid; Fmoc-(R)-3-piperidylacetic acid
EINECS	Contact for details

Quality Control

Every batch of 2-[(3R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Piperidin-3-Yl]Acetic Acid is manufactured under strict quality management systems. We guarantee high chiral purity and chemical integrity, supported by comprehensive analytical testing including HPLC, NMR, and optical rotation analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.