Description

Fmoc-β-Imidazolyl-D-Ala is a specialized, non-natural amino acid derivative used in advanced peptide synthesis. This compound is critical for introducing the unique β-imidazolyl-alanine side chain with Fmoc protection, enabling precise control over peptide structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of complex peptides containing histidine-like analogs.
• Peptidomimetic Drug Discovery: Used to create modified peptide backbones with enhanced stability, bioavailability, or specific receptor binding properties.
• Biochemical Research: Employed in the study of enzyme mechanisms, metal ion binding sites, and protein-protein interactions where the imidazole functionality is crucial.
• Libraries for High-Throughput Screening (HTS): Incorporated into combinatorial peptide libraries to identify new lead compounds with potential biological activity.
• Conjugation and Labeling: Serves as a handle for the site-specific conjugation of fluorophores, biotin, or other tags to peptides.

Basic Information

Product Name	Fmoc-β-Imidazolyl-D-Ala
CAS No.	1217735-06-2
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	Fmoc-β-Imidazolyl-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1H-imidazol-4-yl)-D-alanine; Fmoc-D-β-(4-imidazolyl)alanine; Fmoc-3-(1H-Imidazol-4-yl)-D-alanine; Fmoc-His(D-Ala-OH); Fmoc-protected β-imidazolyl-D-alanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-β-Imidazolyl-D-Ala is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and consistency suitable for sensitive research and development applications. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.