Description

(R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid is a high-purity, non-natural amino acid derivative featuring a thiophene side chain and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural and electronic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides containing thiophene-based unnatural amino acids.
• Peptidomimetic Drug Discovery: Serves as a crucial intermediate for creating peptide-like molecules with enhanced metabolic stability, bioavailability, and target affinity.
• Chemical Biology Probes: Used in the synthesis of labeled or tagged peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Pharmaceutical Intermediate: A chiral synthon in the multi-step synthesis of potential active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	(R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid
CAS No.	1217706-09-6
Molecular Formula	C21H17NO4S
Molecular Weight	379.43 g/mol
Synonyms	Fmoc-(R)-3-Thienylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-3-yl)acetic acid; Fmoc-R-3-Thg-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-thienyl-D-glycine; Fmoc-D-3-thienylglycine; N-α-Fmoc-3-thienyl-D-glycine; D-3-Thienylglycine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our (R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-2-(Thiophen-3-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.