Description

n-Fmoc-5,5-Dimethyl-L-Norleucine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for introducing sterically hindered, hydrophobic side chains into peptide sequences, enhancing their metabolic stability and conformational rigidity. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who are developing novel therapeutic peptides, peptidomimetics, and protein engineering tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Peptidomimetic Drug Development: Used to incorporate the unique 5,5-dimethylnorleucine residue, which can improve a peptide's resistance to enzymatic degradation and modulate its binding affinity.
• Structure-Activity Relationship (SAR) Studies: Employed to investigate the impact of bulky, branched side chains on peptide bioactivity and physicochemical properties.
• API Intermediate Synthesis: Serves as a chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) with specific steric requirements.
• Bioconjugation and Labeling: The Fmoc-protected amino group allows for selective deprotection and subsequent conjugation with fluorescent dyes, biotin, or other functional molecules.
• Academic and Industrial R&D: A valuable reagent for exploring novel peptide architectures in academic laboratories and corporate R&D departments focused on next-generation biologics.

Basic Information

Product Name	n-Fmoc-5,5-Dimethyl-L-Norleucine
CAS No.	1217704-60-3
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-Dimethylnorleucine-OH; Fmoc-5,5-Dimethyl-L-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5,5-dimethyl-L-norleucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5,5-dimethylhexanoic acid; Fmoc-Dml-OH; Fmoc-DiMeNle-OH; Fmoc-(5,5-Me2)Nle-OH; Fmoc-2-amino-5,5-dimethylhexanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-5,5-Dimethyl-L-Norleucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric excess, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.