Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-3-(4-Fluoro-Phenyl)-2-Hydroxypropionic Acid is a sophisticated, optically pure amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group, serving as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high stereochemical fidelity and reliable protection chemistry for the amino functionality. It is primarily utilized by the pharmaceutical and biotechnology industries for the development of novel peptide-based therapeutics, diagnostic agents, and other bioactive molecules where precise molecular architecture is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental monomer for the automated, sequential assembly of custom peptides.
• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological or metabolic disorders.
• Proteomics Research: Used in the synthesis of peptide substrates, inhibitors, or standards for enzyme activity studies and biomarker discovery.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new lead compounds with therapeutic potential.
• Bioconjugation: The reactive carboxyl and protected amino groups allow for its incorporation into antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Material Science: Can be used to synthesize functionalized polymers or surfaces with specific biological recognition properties.

Basic Information

Item	Details
Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-3-(4-Fluoro-Phenyl)-2-Hydroxypropionic Acid
CAS No.	1217694-49-9
Molecular Formula	C24H20FNO5
Molecular Weight	421.42 g/mol
Synonyms	Fmoc-(2R,3R)-3-Amino-3-(4-fluorophenyl)-2-hydroxypropionic acid; (2R,3R)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-(4-fluorophenyl)-2-hydroxypropanoic acid; Fmoc-3-Amino-3-(4-fluoro-phenyl)-D-β-hydroxypropionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(4-fluorophenyl)-D-β-hydroxypropionic acid; Fmoc-AHP(4-F)-OH; Fmoc-D-3-Amino-3-(4-fluorophenyl)-2-hydroxypropionic acid
EINECS	Contact for details

Quality Control

Our n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-3-(4-Fluoro-Phenyl)-2-Hydroxypropionic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.