Description

Boc-α-Methyl-L-Aspartic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical building block for introducing a modified aspartic acid residue with a chiral α-methyl group, enabling the study of peptide conformation, stability, and biological activity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutics, enzyme inhibitors, and bioactive peptides.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Medicinal Chemistry Research: Used to incorporate conformationally constrained, non-natural amino acids into peptides to modulate their pharmacokinetic properties and receptor binding affinity.
• Protease Inhibitor Development: Essential for creating substrate analogs and inhibitors targeting aspartic proteases due to its modified side chain.
• Bioconjugation & Labeling: The Boc-protecting group allows for selective deprotection, facilitating site-specific modifications and labeling of peptides.
• Academic & Institutional Research: Employed in studies exploring peptide structure-activity relationships (SAR) and enzyme mechanisms.
• Pre-clinical Candidate Synthesis: Used in the development and scale-up of peptide leads for pre-clinical evaluation.

Basic Information

Product Name	Boc-α-Methyl-L-Aspartic Acid
CAS No.	1217679-66-7
Molecular Formula	C10H17NO6
Molecular Weight	247.25 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-2-methylbutanedioic acid; N-(tert-Butoxycarbonyl)-α-methyl-L-aspartic acid; Boc-α-Me-L-Asp-OH; Boc-Asp(α-Me)-OH; N-Boc-α-methyl-L-aspartic acid; tert-Butyloxycarbonyl-α-methyl-L-aspartic acid; (S)-2-((tert-Butoxycarbonyl)amino)-2-methylsuccinic acid
EINECS	Contact for details

Quality Control

Our Boc-α-Methyl-L-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.