Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-(4-Methyl-Phenyl)Propionic Acid is a sophisticated, optically pure amino acid derivative protected with the Fmoc group. This compound matters as a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in oncology and metabolic disease research.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid monomer for the automated assembly of custom peptide sequences.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs) requiring specific (2R,3R) stereochemistry.
• Peptidomimetic Design: Acts as a scaffold for creating non-peptide compounds that mimic peptide bioactivity, enhancing metabolic stability.
• Chemical Biology Probes: Incorporated into labeled peptides for studying protein-protein interactions and enzyme mechanisms.
• Catalyst and Ligand Synthesis: Utilized in the preparation of chiral catalysts or ligands for asymmetric synthesis.
• Academic and Contract Research: Employed in university and CRO laboratories for fundamental research in medicinal chemistry and biochemistry.

Basic Information

Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-(4-Methyl-Phenyl)Propionic Acid
CAS No.	1217669-56-1
Molecular Formula	C25H23NO5
Molecular Weight	417.46 g/mol
Synonyms	Fmoc-(2R,3R)-3-Amino-2-hydroxy-3-(p-tolyl)propanoic acid; Fmoc-Ahp(4-Me)-OH; (2R,3R)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-3-(4-methylphenyl)propanoic acid; (2R,3R)-Fmoc-3-amino-2-hydroxy-3-(4-methylphenyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-hydroxy-3-(4-methylphenyl)-(2R,3R)-propanoic acid; Fmoc-D-β-hydroxy-4-methylphenylalanine; Fmoc-3-Amino-2-hydroxy-3-(4-methylphenyl)-(2R,3R)-propionic Acid
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral building block adheres to strict in-process controls to ensure stereochemical integrity and batch-to-batch consistency. Every lot is fully characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.