Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-Phenylpropionic Acid is a high-purity, stereochemically defined amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling precise control over molecular architecture. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic agents, diagnostic probes, and bioactive compounds where the (2R,3R) stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, receptor antagonists, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Essential Fmoc-protected amino acid for automated and manual solid-phase peptide synthesis (SPPS) to produce research and therapeutic peptides.
• Bioconjugation: Used to introduce specific functional handles into biomolecules for drug-antibody conjugates (ADCs) or labeling applications.
• Chemical Biology Research: Building block for constructing peptide libraries and molecular probes to study protein-protein interactions and enzyme mechanisms.
• Process Development: Serves as a reference standard and starting material for scaling up the production of chiral compounds in process chemistry.

Basic Information

Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-Phenylpropionic Acid
CAS No.	1217665-32-1
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-(2R,3R)-3-Amino-2-hydroxy-3-phenylpropionic acid; (2R,3R)-2-Hydroxy-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-phenylpropanoic acid; Fmoc-AHPPA-OH; Fmoc-D-three-β-Hydroxy-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-three-β-hydroxy-phenylalanine; N-Fmoc-D-three-β-Hydroxyphenylalanine; (2R,3R)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2R,3R)-3-Amino-2-Hydroxy-3-Phenylpropionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.