Description

4-Aminomethyl-D-Phenylalanine is a non-natural, enantiomerically pure amino acid derivative of significant interest in advanced pharmaceutical research and development. Its unique structure, featuring a D-configuration and a primary amine side chain, makes it a critical building block for the synthesis of complex peptides and peptidomimetics. This high-purity chiral intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic agents, diagnostic tools, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to create stable, bioavailable peptide analogs with enhanced metabolic stability and receptor selectivity.
• Conjugation Chemistry: The primary amine group serves as a versatile handle for bioconjugation, linking peptides to payloads, labels, or polymers.
• Research & Development: A valuable tool in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Diagnostic Agent Synthesis: Incorporated into the structure of imaging probes and contrast agents for diagnostic applications.
• Ligand Development: Used in the creation of specific ligands for receptors and enzymes in biochemical assays.

Basic Information

Product Name	4-Aminomethyl-D-Phenylalanine
CAS No.	1217662-97-9
Molecular Formula	C10H14N2O2
Molecular Weight	194.23 g/mol
Synonyms	D-4-(Aminomethyl)phenylalanine; (R)-2-Amino-3-[4-(aminomethyl)phenyl]propanoic acid; H-D-Phe(4-CH2NH2)-OH; D-4-Aminomethylphenylalanine; Fmoc-D-Phe(4-CH2NH2)-OH (protected form); D-4-(Aminomethyl)phenylalanine hydrochloride (salt form); Boc-D-Phe(4-CH2NH2)-OH (protected form); D-Phenylalanine, 4-(aminomethyl)-
EINECS	Contact for details

Quality Control

Our 4-Aminomethyl-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.