Description

Fmoc-D-Dab(Fmoc)-Oh is a high-purity, orthogonally protected diaminobutyric acid derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the D-isomer of 2,4-diaminobutyric acid (D-Dab) into peptide chains, enabling the creation of complex, non-natural peptide structures with enhanced stability and specific biological activity. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the R&D of novel peptide drugs, including antimicrobial peptides (AMPs) and hormone analogs.
• Peptidomimetic Design: Incorporation into engineered peptides to improve metabolic stability, bioavailability, and target binding affinity.
• Bioconjugation: Serves as a versatile linker or spacer molecule in the creation of peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Essential for synthesizing labeled or tagged peptides used in mechanistic studies and target identification.
• API Intermediate: Acts as a critical raw material in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for GMP manufacturing.

Basic Information

Product Name	Fmoc-D-Dab(Fmoc)-Oh
CAS No.	1217645-10-7
Molecular Formula	C34H30N2O6
Molecular Weight	562.61 g/mol
Synonyms	Fmoc-D-Dab(Fmoc)-OH; Nα,Nω-Bis(9-fluorenylmethoxycarbonyl)-D-2,4-diaminobutyric acid; (R)-2,4-Bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid; D-Dab(Boc)-OH (common precursor); Fmoc-D-2,4-diaminobutyric acid(Fmoc)-OH; Nα-Fmoc-Nω-Fmoc-D-diaminobutyric acid; BOC-D-Dab(FMOC)-OH (related compound); D-2,4-Diaminobutyric acid bis-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dab(Fmoc)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.