Description

L-Selenomethionine-(Methyl-13C) is a stable isotope-labeled analog of the essential amino acid selenomethionine, where the methyl group is enriched with carbon-13. This compound is critical for advanced research in metabolic tracing, protein turnover studies, and the development of highly sensitive analytical methods. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, nutritional science, and clinical diagnostics who require precise isotopic labeling for mass spectrometry-based quantification and metabolic pathway analysis.

Application

• Isotopic Tracer in Metabolic Studies: Used to investigate the metabolism, absorption, and bioavailability of selenium and methionine in biological systems.
• Internal Standard for Mass Spectrometry: Serves as a critical quantitative standard in LC-MS/MS and GC-MS assays for accurate measurement of selenomethionine in complex matrices like plasma, tissues, and nutritional supplements.
• Pharmaceutical Research: Employed in the development and validation of assays for selenium-containing drug candidates and in studying selenium's role in chemoprevention.
• Nutritional and Clinical Research: Facilitates studies on selenium deficiency, supplementation efficacy, and its role in antioxidant defense mechanisms.
• Stable Isotope Labeling in Proteomics: Used in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other proteomic techniques for protein quantification and dynamics.
• Reference Material Production: Acts a high-purity calibrant for diagnostic kits and certified reference materials (CRMs) in food and clinical testing.

Basic Information

Product Name	L-Selenomethionine-(Methyl-13C)
CAS No.	1217470-45-5
Molecular Formula	C13CH3-Se-CH2-CH2-CH(NH2)-COOH or C513CH3H11NO2Se
Molecular Weight	~198.1 g/mol (for 13C1 labeled form)
Synonyms	(2S)-2-Amino-4-[(13C)methylselanyl]butanoic acid; L-(Methyl-13C)Selenomethionine; SeMet-13C1; Seleno-L-methionine (methyl-13C); (S)-2-Amino-4-((13C)methylseleno)butyric acid; L-SeMet-(13CH3); Stable Isotope Labeled Selenomethionine; 13C-Labeled Selenomethionine
EINECS	Contact for details

Quality Control

Our L-Selenomethionine-(Methyl-13C) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and isotopic purity, meeting the exacting requirements of research and diagnostic applications. Certificates of Analysis (COA) are provided, detailing parameters such as assay (by HPLC), isotopic enrichment (by NMR or MS), chiral purity, and related substances. We support compliance with relevant guidelines for GMP and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: Specific range provided per COA
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.