Description

(S)-1-(2,3-Difluoro-4-Methylphenyl)Ethanamine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, fluorinated aromatic core essential for developing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated fluorinated chemical architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the difluoromethylphenyl moiety can influence biological activity.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers with unique properties.
• Process Chemistry: Used in route scouting and scale-up studies for the commercial manufacturing of complex molecules.

Basic Information

Product Name	(S)-1-(2,3-Difluoro-4-Methylphenyl)Ethanamine Hydrochloride
CAS No.	1217467-70-3
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	(S)-1-(2,3-Difluoro-4-methylphenyl)ethan-1-amine hydrochloride; (S)-α-Methyl-2,3-difluoro-4-methylbenzylamine hydrochloride; (S)-1-(2,3-Difluoro-p-tolyl)ethylamine hydrochloride; (S)-(-)-1-(2,3-Difluoro-4-methylphenyl)ethylamine HCl; (S)-2,3-Difluoro-4-methyl-α-methylbenzylamine hydrochloride; (S)-Enantiomer of 1-(2,3-Difluoro-4-methylphenyl)ethanamine HCl
EINECS	Contact for details

Quality Control

Our (S)-1-(2,3-Difluoro-4-Methylphenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.