Description

L-Phenylalanine-13C9,15N, n-Fmoc Derivative, n-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine-13C9,15N is a highly specialized, isotopically labeled amino acid derivative essential for advanced research and development. This compound serves as a critical building block for the synthesis of peptides and proteins containing stable isotope labels, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical researchers, analytical chemists, and biochemists in drug discovery, proteomics, and mass spectrometry applications where high-purity, traceable materials are non-negotiable.

Application

• Stable Isotope Labeling in Peptide Synthesis: Used as a labeled precursor for the solid-phase or solution-phase synthesis of isotopically tagged peptides for quantitative proteomics and biomarker discovery.
• Internal Standards for Mass Spectrometry (MS): Essential for developing accurate and sensitive LC-MS/MS methods for the quantification of phenylalanine-containing peptides or metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Employed in in vitro and in vivo studies to track the incorporation and fate of phenylalanine in metabolic flux analysis and drug metabolism research.
• Structural Biology & NMR Studies: Facilitates nuclear magnetic resonance (NMR) spectroscopy by providing site-specific 13C and 15N labels for detailed protein structure and dynamics analysis.
• Pharmaceutical R&D: A key intermediate in the research and development of novel therapeutic peptides and antibody-drug conjugates (ADCs) requiring isotopic labeling.
• Academic Research: Supports fundamental biochemical research in universities and institutes focused on protein engineering, enzyme mechanisms, and amino acid metabolism.

Basic Information

Item	Details
Product Name	L-Phenylalanine-13C9,15N, n-Fmoc Derivative
CAS No.	1217455-27-0
Molecular Formula	C24H1913C915NO4
Molecular Weight	~460.4 g/mol (for 13C9, 15N labeled form)
Synonyms	Fmoc-Phe(13C9,15N)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine-13C9,15N; N-Fmoc-L-phenylalanine-13C9,15N; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-phenylpropanoic-13C9,15N acid; Fmoc-L-phenylalanine (phenyl-13C9,15N); Fmoc-Phe(13C9,15N); Isotopically labeled Fmoc-phenylalanine; 9-Fluorenylmethyloxycarbonyl-L-phenylalanine-13C9,15N
EINECS	Contact for details

Quality Control

Every batch of our isotopically labeled Fmoc-L-Phenylalanine-13C9,15N is manufactured and tested under stringent quality systems to ensure exceptional chemical and isotopic purity, critical for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing specifications for isotopic enrichment, chiral purity, and chemical purity, typically assessed by advanced techniques including NMR, HPLC, and mass spectrometry. Our commitment to traceability and consistency supports compliance with the rigorous demands of GLP and GMP environments in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (15N)	≥ 98 atom % 15N
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.