Description

Fmoc-Ser(Tbu)-Oh-13C3,15N is a stable isotope-labeled derivative of the amino acid serine, specifically engineered for advanced research and analytical applications. This compound is essential for quantitative proteomics and metabolic flux analysis, where it serves as a critical internal standard to ensure precise and accurate mass spectrometry measurements. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and CROs specializing in peptide synthesis, biomarker discovery, and drug metabolism studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used in quantitative proteomics (e.g., SILAC, AQUA) for accurate protein quantification and biomarker validation.
• Metabolic Pathway Tracing: Employed in 13C and 15N metabolic flux analysis to study cellular metabolism and biosynthesis pathways.
• Isotope-Labeled Peptide Synthesis: A key building block for the solid-phase synthesis of isotopically labeled peptides used as reference materials.
• Pharmaceutical Development: Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolites and understand drug mechanisms.
• Nutritional and Clinical Research: Applied in tracer studies to investigate protein turnover, amino acid metabolism, and related disorders.
• Quality Control & Method Development: Serves as a high-purity reference standard for calibrating analytical instruments and validating LC-MS/MS methods.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Oh-13C3,15N
CAS No.	1217448-78-6
Molecular Formula	C22H2213C315NO6
Molecular Weight	~ 414.4 g/mol (for labeled form)
Synonyms	Fmoc-Ser(O-t-Bu)-OH-13C3,15N; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-serine-13C3,15N; Fmoc-O-tert-butyl-L-serine-13C3,15N; Fmoc-L-Ser(tBu)-OH-13C3,15N; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxy]propanoic-13C3,15N acid; Isotopically labeled Fmoc-Ser(Tbu)-OH; Stable isotope-labeled Fmoc-Ser(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Oh-13C3,15N is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., 13C, 15N), chemical purity by HPLC, and chiral purity. We support compliance with relevant GMP/GLP guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (15N)	≥ 98 atom %
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.